pentobarbital boosts toxicity of buprenorphine, extensive-acting injection by pharmacodynamic synergism. Modify Therapy/Check Intently. Coadministration of buprenorphine and benzodiazepines or other CNS depressants improves threat of adverse reactions which include overdose, respiratory melancholy, and death. Cessation of benzodiazepines or other CNS depressants is preferred typically.

pentobarbital will lower the level or result of buprenorphine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

pentobarbital will reduce the extent or impact of theophylline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will lessen the extent or impact of bosentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Mysterious.

pentobarbital will reduce the level or impact of bazedoxifene/conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

pentobarbital will reduce the extent or influence of triamcinolone acetonide injectable suspension by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

After halting a CYP3A4 inducer, as the effects from the inducer decline, the fentanyl plasma focus will increase which could improve or prolong both the therapeutic and adverse effects.

pentobarbital will minimize the level or influence of ramelteon by affecting hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Unidentified.

pentobarbital will decrease the level or influence of stiripentol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If struggling to stay away from coadministration of stiripentol with solid CYP3A4 inducers, increase stiripentol dose.

pentobarbital will reduce the level or result of aprepitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

Data are at present not available to Examine influence of barbiturates when forceps shipping and delivery or other intervention is critical; also, information usually are not offered to determine the influence of these barbiturates over the later on advancement, enhancement, and practical maturation of the kid

Immediately after halting a CYP3A4 inducer, given that the effects from the inducer decline, the fentanyl plasma concentration will increase which could increase or prolong get more info the two the therapeutic and adverse effects.

pentobarbital will lessen the level or effect of propafenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.

pentobarbital will decrease the extent or outcome of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.